Sylvia Plath and Spirited Away Essay Example for Free

Sylvia Plath and Spirited Away Essay The inner journey is a metaphysical process in which an individual travels into their own psyche often resulting in form of self realization. Although the journey is not physical, an inner journey is a powerful tool in which one can enhance their knowledge of the world and their own human nature, commonly encountering imaginative obstacles which assist in the individual’s self-realization. The texts that I will use to illustrate the inner journeys are â€Å"You’re† and â€Å"A Birthday Present† by Sylvia Plath and The animated film â€Å"Spirited Away† directed by Hayao Miyazaki. Sylvia Plath utilizes the inner journey as a way to explore aspects of her life through the medium of poetry. Her poem â€Å"You’re† explores the emotional journey of an expecting mother, using poetic techniques to highlight the joys and mysteries of the baby in the womb, In contrast to Sylvia Plath’s poem â€Å"A Birthday Present† which explores the persona’s fear of death, despite desperation to end ones life, effectively using techniques to highlight the fear and want for death. Comparatively Hayao Miyazaki utilizes his film â€Å"Spirited Away† to demonstrate the protagonist’s, Chihro journey to develops and overcome circumstances to become a self-sufficient and self-reflective girl, by emphasizing the development with camera techniques and layout of particular scenes. These texts demonstrate the importance of inner journeys, demonstrating how journeys result in knowledge of their own nature and the world around them. Plath’s poem â€Å"You’re† conveys, a deep sense of joy and excitement, as a mother goes through the emotional journey, going through the delight of bearing a child, while still going through the mysterious and vagueness of the child referencing it to the furthest place imagined, for the persona â€Å"farther off than Australia†. Plath uses a range of techniques to express the joy of bearing a child and the warm comfort of it being â€Å"wrapped up in yourself like a spool†, the simile reinforces the idea of always being safe and loved, as well as the metaphor â€Å"Snug as a bud† creating the sense of the small baby being safe. It can also be lively and playful â€Å"Jumpy as a Mexican bean† all the techniques restate that the journey so far is positive and delightful and how she continues to try to understand her coming child with similes â€Å"like a sprat in a pickle jug†. However the mother experiences the mysteries and vagueness of the unborn child, noting her difficulty in describing it, she relies on terms from the world she knows for example â€Å"gilled like a fish† comparing it to a fish as it is all wrinkled and complex, as well as describing it as a â€Å"travelled prawn† and â€Å"moon skulled†, we understand the difficulty of understanding how it looks. The mother continues to try describing and understand the child she is about to have using the metaphor â€Å"vague as fog† to show how mysterious and undefined the child is, yet it is still eagerly anticipated and â€Å"looked for like mail† showing no matter what, the mother is overcome by joy on having the child. The Mother ventures through all these emotions, grasping to understand the unborn child, using similes and metaphors to figure out how the child may be and reflecting upon the joy of it all. Recognizing the uniqueness of the child arriving with its â€Å"own face†. Comparatively Sylvia Plath’s â€Å"A Birthday Present† deals with the persona inner battle of to decide to live on. â€Å"A birthday Present† is an extended metaphor, symbolizing death, allowing the audience to understand the shocking irony of the poem and the persona’s real want of what is â€Å"behind this veil†. However the fear of death is the only obstacle stopping the persona from killing themselves. The inner journey which is present in this poem is of the personas hesitation to kill herself she â€Å"would not mind if it were bones, or a pearl button† demonstrating her want for something tangible, Questioning her inner self if she actually wants it â€Å"can you not give it to me? † the change of voice to reassure herself. Tempting and luring her inner self to choose death with the continuous repetition of â€Å"let down the veil, the veil, the veil†. Ultimately the persona is fearful of death stating â€Å"You are terrified† confirming to herself that she is unsure reinforced by the simile â€Å"shimmering like curtains† reflecting the unstable curtains as her uncertainty. However her pessimistic outlook upon life and repetitious suppression of adhering to rules, to rules, to rules† gives her the strength to take her life. Her cynical tone â€Å"My god what a laugh† gives her courage to the view the world pessimistically and take her life, as well as continuously referring her life with little importance â€Å"I will only take it and go aside quietly†, â€Å"A marvel to your grandchildren †¦ it is not so† stating that no one will care after she is gone. The persona is now definite about taking her life and that â€Å"only you can give it to me†, representing now that behind the veil is death and how she asks for a quick death â€Å"you will not hear me opening it†. And that there is nothing left to fear as â€Å"the universe slide[s] from my side†, showing that through the inner journey the persona was able to understand the pessimistic world around her and how utilizing repetition, rhetorical questions and cynical tone to find the courage to no longer fear death. Comparatively â€Å"Spirited Away† is both a mental and physical journey to save her parents, which results in the growth and self-realization of Chihiro’s true self, facing challenges that allow Chihiro to learn lessons such as patience and understanding to survive and return home, with important scenes and symbolic items throughout the film to represent Chihiro’s growth. Chihiro was bought up in materialistic and idle world â€Å"don’t worry, you’ve got Daddy here. He’s got credit cards and cash† as well shown when Chihiro lying on the backseat, which is in shocking transition to when Chihiro has to work for herself in the bath house. At first she works ineffectively with other workers commenting â€Å"get out of the way†, representing her incompatibility and unwelcomed arrival, however she slowly progresses and gradually through the determination to save her parents becomes better, with the scene of washing of the stink spirit determining her capabilities to grow and become accepted, with rejoicing music and cheers from fellow workers, showing a close up a shot of Chihiro showing a sense a achievement and happiness, demonstrating Chihiro’s growth of maturity through working at the bath house. In comparison we learn Chihiro is a stoic young girl fearful of changes, shown in the first scene when her flowers start to die representing her old life wilting away. Yubaba takes away Chihiro’s name, she appears completely frightened, whimpering and shaking in a close up shot when Yubaba, and only takes the job to survive. Chihro clings desperately to her old self shown crying and curling up in a ball, with classical music playing in the background emphasizing the scene. Yet during her time as Sen her true self develops, showing unconditional compassion and kindness to several of the bathhouse inhabitants, especially Haku. One particular scene when Sen climbs the bathhouse to reach Haku, demonstrates her growth to protect Haku, even when endangering her life. Using the low angle camera shot to add to the enormity of seeing Chihiro on the roof tying her clothes, to risk her life to save Haku, portraying Chihiro’s growth to not only face her fears, but do so for others. She develops to also be able to stand up to Yubaba, in the final test, a high angle long shot, shows Chihiro striding confidently across the bridge as well as a close up of Chihiro’s determined face while facing Yubaba, depicting Chihiro no longer a scared frightened girl that she used to be. In â€Å"Spirited Away† Chihiro goes on a inner journey, which develops her from the immature, fearful child to the self-sufficient and self-reflective young girl, portrayed by the camera angles and shots and symbolism.

Essay --

Yves Henri Donat Mathieu-Saint-Laurent, known as Yves Saint Laurenta was born January 1, 1956 in Oran, French Algerian. His family consisted of his mom, Lucienne-Andree, dad, Charles & two younger sisters Michele & Brigitte. As Yves was growing up he was bullied constantly. When Yves went home he found refuge by looking throuh VOUGE Magazines & fell inlove with the descriptions & outfits. Yves started out making paper difficut cut out dolls and designing them. Time pass & he got into designing & making dresses for his mother and sister based of the ones on the VOUGE magazines that caught his eye. In one of the magazines that Yves read their was a contest for young fashion designers, organized by the International Wool Secretariat. Yves submitted 3 of his favorite sketches. He won first place and was invited to attend the awards ceremony in Paris, in December of that year (1953). While he and his mother were in paris, they met the editor & chief of the VOUGE magazine, Michel de Brunho ff. Michael-De-Brunnoff was impressed by the sketches Yves brought with him and suggested he become a fashion designer. Yves followed his advice. Leaving Oran for Paris after graduation, began his studies there and eventually graduated as a star pupil. The next year, (1954) Yves considered a course at Chambre Syndicale de la Haute Couture, the council which regulates the Haute Couture industry and provides training to its employees. Later that same year, he entered the International Wool Secretariat competition again and won, beating out his friend Fernando Sà ¡nchez and young German student Karl Lagerfeld. Later after his win, he brought a number of sketches to de Michael who recognized close similarities to sketches he had been shown that morning by Ch... ...he decade, with Saint Yvez slowing down his work pace, he and Berge had sold the company they'd started, netting the two men a fortune.In January 2002, Yvez participated in his final show and then retired for good in Marrakech. Five years later, Saint Laurent's imprint and importance on French culture was cemented when he was appointed Grand Officer of the Legion d'honnerur by French President, Nicolas Sarkozy. Yves Saint Laurent later passed away in Paris on June 1, 2008 after a brief illness. YSL Company Head-Quarters Located in New York City 10022 3 E 57th Street Corporate Phone Number: 1-212-832-7100. Yves Henri Donat Mathieu-Saint-Laurent a.k.a. Yves Saint Laurent is a famous French fashion designer credited with developing â€Å"Le Smoking,† a tuxedo made just for women. The tuxedo design earned the attention of other designers like CoCo Chanel, Pierre Cardin and K

Microarray Student

In the cell cytoplasm, the ribosome reads the sequence of the Mrs. in groups of three bases to assemble the protein. D. What is the resulting primary sequence Of the protein you made in the interactive? Mennonite, Lucien, Aspartic Acid, Valise, Phenylalanine 2. Go to the â€Å"DNA Microfarad Virtual Lab† found at the university of Tutu's Learn-Genetics: Genetic Science Learning Center's website: http://learn. Genetics. Utah. Du/content/labs/microfarad/ 3. Click on the microfarad slide to begin. Then choose Chapter 2 â€Å"Measuring Gene Expression† and go on through Chapter 3 â€Å"The Experiment†.Complete the interactive a first time without writing anything down. 4. Answer the following questions as you work through the virtual DNA microfarad a second time. . What can scientists look for to see which genes are turned on in a particular cell? Provide an example. Scientists use DNA microfarad's that used techniques allowing the amount of Mrs. transcribed by each gene which allows scientists to determine which genes are expressed to a cell. To do so, they use PC to make copies of a gene and then DNA is placed on the microfarad.An example of this is when the DNA microfarad's can be used to detect single nucleotide polymorphisms (Snaps). B. Why are tissue samples from healthy and cancer cells taken from the same patient? Both samples are elected to be able to compare the cells, look at differences in gene expression in cells that have the exact genetic blue print. C. How is RNA separated from the rest of the tissue? In order to be separated, RNA samples are mixed with organic solvents, and then they run through a vortex and centrifuge. D. Describe the process used to isolate Mrs. from the other types of RNA. RNA is different from other types of RNA because it is the only type that has Poly-A tails, having several adenine amino acids at the end of the molecule. E. Explain how samples are marked. Cancerous cells are red and healthy cells are gre en. . Why is it necessary to make a CDMA copy? Why is Mrs. not used? RNA is not used because DNA is a more stable compared to RNA Making a CDMA copy is necessary to visualize the CDMA later on. This is possible because when you make the CDMA copy, you incorporate a fluorescent label in the molecule. G.Draw a diagram of the process of how labeled DNA copies are made. Label the important components of the process. Your diagram should be in color. Turned in. H. What does CDMA stand for and what was used as a template to create it? CDMA stands for complimentary DNA fragments. The reverse transcription of Mrs. allows for single stranded CDMA to be made. I. What happens once you apply the DNA from the two samples to the DNA microfarad? On the microfarad there are many identical copies of the same genes on certain spots, each spot represents a different gene. J. What does the red color indicate?The red color indicates genes that were induced by elevated CA. K. What does the green color ind icate? The green color indicates that the gene was strongly repressed by cancer cells. L. What does the yellow color indicate? The yellow color indicates that the gene was neither strongly expressed nor strongly repressed in cancer cells. . What conclusions can you make from microfarad data? Microfarad data is a collection Of DNA spots attached to a solid surface that's used to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. . Does every red spot mean that the genes in that spot are bad? Explain. Not every red spot is cancerous. Red spots on the merged image represent genes that have had their expression turned up or on in the cancerous tissues and are not expressed in normal cells, the they are not always cancerous. O. What are the limitations of DNA microfarad technology? The quality and amount of RNA remains a major challenge in the microfarad experiments. The amount of obtained tissue and the complexity of the t issue sample itself limit the quality and quantity of RNA that can be isolated.Therefore, clinical studies that are published using the microfarad approach are performed in settings where biological samples are abundant and easily obtainable. 5. Complete the Paper Microfarad analysis that comes with the kit. Part II: Smoking and Lung Cancer Grandpa Joe, Judy Smith's father, has been a smoker for the past thirty years. Last year, Grandpa Joe came down with a cold that turned into pneumonia. It took him more than a month to recover. The family is very concerned he is going to develop lung cancer.They heard about a study being conducted at the local hospital that is exploring lung-cancer associated genes in smokers and non-smokers. The family convinces Grandpa Joe to participate in the study in order to learn more about his risk for developing lung cancer. The study is investigating six genes thought to be involved with lung cancer using DNA microfarad technology. The researchers hope to compare gene expression of the six genes of interest between smokers and non-smokers in order to gain more knowledge of what causes a normal lung cell to become cancerous.You have been assigned to the study. Your first task is to learn more about the six genes of interest. Below are descriptions for the six genes of interest: Gene Name (and Symbol): Protein Function: Prediction: Gene l: Human carcinogenicity antigen (CANDACE) This gene codes for a protein that is located in the extracurricular matrix. This protein is involved with adhesion between cells and is thought to be a proto- nosecone and when over-expressed is an nosecone. Expressed in smoker. We predict that the CANDACE will progress to the form of a tumor or untie to harbor that potential.Gene 2: Surfactant protein B (SIFTS) This gene codes for an extracurricular protein. This protein enhances the rate of spreading and increases the stability of pulmonary' surfactant, a lipid-rich material that prevents lung collapse by lowering surface tension at the air- liquid interface in the alveoli of the lungs. Expressed in the Smoker. This gene can possibly progress to spread a higher production of cells or possibly a higher rate of cancer, maybe in the lungs. Gene 3: POP tumor suppressor (HTTP) This gene codes for a protein that is located in the mitochondria and in the nucleolus.This protein is involved with cell cycle checkpoints. This gene is a tumor suppressor gene and is thought to be the â€Å"Guardian of the Genome. † Suppressed in the smoker. I predict this gene is unlikely to get cancer as it monitors cell production, etc. To prevent tumors. Gene 4: CRY This gene codes for a protein that is located in the nucleus. The protein that this gene codes for is testis-determining factor (UDF) which initiates male sex determination. This protein has no function in lung cells. Not expressed in either. Non-smoker-?yellow.This gene probably determines whether or not you get cancer based on cell produc tion. Assume it contributes to getting cancer, unless in the lung cells, where there would be no increase or decrease in likeliness. Gene S: Stockroom IPPP (COPY AY) This gene codes for a protein that is located in the endoplasmic reticulum. The protein catalysts reactions involved in drug metabolism and synthesizes cholesterol, steroids, and other lipids. The expression of this protein is induced by some polycyclic aromatic hydrocarbons (PARS), some of which are found in cigarette smoke.Suppressed in smoker. This gene will contribute to causing cancer if deregulated because it controls cell signaling pathways. Gene 6: Clinical 3(SPEC) This gene codes for a protein that is located in the plasma membrane and extracurricular matrix. The gene controls cellular response to damage and may control cellular growth regulation and apotheosis. This gene is considered to be a tumor suppressor gene for lung cancer. Suppressed in smoker. This gene decreases your risk of cancer as it controls cel l self-destruction and responds to damage or advances in cell growth 6.Highlight or underline any interesting or important information about the function of each protein. 7. Predict how these genes will be expressed in a DNA microfarad of a smoker versus a non-smoker. Would you expect the genes to be induced in the smoker (more expressed), suppressed in the smoker (less expressed), not expressed in either the smoker or the non- smoker, or expressed the same in both the smoker and non-smoker? In a DNA microfarad, I would expect these DNA genes to have a bit of diversity. I think Gene 1 and 2 will be likely induced as they can contribute to overall cell production, 4 would be unaffected as Mr..Smith is testing for lung cancer, and 3, 5, and 6 to be suppressed as they work to control cell production and smoking destroys several of their functions. For example, Gene 6 works to control cell apotheosis– if smoking ruins the chances for a cell to destroy itself, production can get o ut of control. 8. Record your predictions in the Prediction column of the above table. Part Ill: Microfarad Wet Lab Now that you know more about the six genes of interest, your job is to perform a simulated DNA microfarad using tissue samples taken from Grandpa Joe and a non-smoker's tissue samples.

Violence in Video Games Essay example - 2474 Words

Video games first appeared in the early 1970s. It all started with a simple white ball bouncing back and fourth on the screen. In 1986, Nintendo introduced its first line of home video game consoles. With the Nintendo Entertainment System (NES) on the market, the home video gaming industry surged and immediately became popular among children. Since then, not only have video games increased in popularity, but there have been vast improvements in graphics, game play, and forms of gaming. Today, video games have become the preferred choice of entertainment among children and teenagers. Research done in 1998 has shown that kids who own video games spend an average of 90 minutes a day playing them. Clearly the video gaming industry is a†¦show more content†¦Now with the improvements in technology, people dont simply disappear in a cloud of smoke. Today when the enemies die they bleed, they explode, a grotesque image of a corpse remains with the gunshot or cut wound left behind. I n games like Metal Gear Solid 2 for the Playstation 2, the enemies perform elaborate maneuvers when you shoot them. It can even be entertaining to shoot them in different places and see how they react. Shoot them in the arm and it goes limp, shoot their radio and they wont be able to use it, shoot them in the head and blood sprays out. Even though the levels of realism and gore have increased, it can be said that video games have NOT become more violent since the basic goal is the same: shoot and kill everything in your way. Both early video games and todays games contain violence, but is one more acceptable than the other? Some would argue that violence like that in Wonder Boy is an acceptable level of violence, where the violence in Metal Gear Solid 2 is not. Others disagree and say that it doesnt matter what kind of violence there is in games, violence is violence and has the same effect on people. EFFECTS OF VIDEO GAME VIOLENCE With so many popular violent games out there, what are its effect on the people who play them and our society? The U.S. Surgeon General C. Everett Koop once claimed that arcade and home video games are among the top three causes of family violence.Show MoreRelatedThe Effect of Video Game Violence on Physiological Desensitization to Real-life Violence2765 Words   |  12 Pageschildren who play video games for many hours daily. Addiction controls life of people, there is addiction to drugs, cigarettes, alcohol or gambling, and there are some forms of addiction associated with modern life, such as Internet and video games. Most people think that video games are harmful and waste of time. As a result, the main question of the research is how video games can influence on children and many minor questions come to mind about video games: Do video games influence a child’sRead MoreViolent Video Games Cause Increased Violence Essay1855 Words   |  8 Pagesobjective of video games is to entertain people by surprising them with new experiences.† (Shigeru Miyamoto) Shigeru Miyamoto is the creator of some of gaming’s most iconic video game characters, Mario Jumpman Mario, Link and Donkey Kong; while also, serving as co-Representative Director of the game company, Nintendo and is highly respected. Miyamoto, based on the quote provided, feels that video games are meant to entertain people and nothing more. However, many people feel as though video games only causeRead MoreVideo Games : Video Game Violence1502 Words   |  7 Pages2013 Video Game Violence The evolution of video games has taken a drastic change since the 1970’s when video games were first introduced. Since then every decade video games have become more violent in nature with strong language and realistic to suit society today. Craig Anderson states that with more violence in video games they would sell better than games with less violence (Anderson, Gentile, and Beckley pg.5). Violent video games really became popular when the first person shooter games wereRead MoreVideo Games : Video Game Violence Essay1693 Words   |  7 PagesVideo Game Violence Blood and gore, intense violence, strong sexual content, use of drugs. These are just a few of the phrases that the Entertainment Software Rating Board (ESRB) uses to describe the content of several games. The future of entertainment revolves around technology. Along with the evolvement of technology, video games are also changing. More ways of playing violent video games are created each year, but most of us have this question in mind; do violent video games influence peopleRead MoreVideo Game Violence : Video Games892 Words   |  4 PagesVideo Game Violence On December 14, 2012, a twenty year old boy named Adam Lanza shot twenty children and six staff at Sandy Hook Elementary School in Newtown, Connecticut. Before arriving to the school, he shot his mother then committed suicide after the shooting. The reports say that he was influenced to shooting others by the video game â€Å"Call of Duty†. Video game violence is defined as a behavior including physical violence intended to hurt, damage, or kill someone or something impacted by videoRead MoreVideo Games : Violence And Violence1301 Words   |  6 PagesThe issue of violence in these media products has been a highly-debated issue for the past few decades. Recently it has become extremely popular in the subject of violence in video games. It is rumored that games such as â€Å"Call of Duty, Mortal Kombat, Battlefield, Halo and many more have been the culprit behind a recent spike in childhood aggression. Many people have their own views on the subject, but it has been most com monly deduced that aggression is caused by the games, but violence does not alwaysRead MoreVideo Games and Violence942 Words   |  4 Pages Video Games and Violence Awe entering in more advanced society of technology, video games has become a popular source of entertainment among us. Almost all of us has rented or owned a video game and we have spent hours playing it. As we all know, video games have become the second most popular form of entertainment after television; the source of entertainment is proven to be violent. Excessive playing of video games has a huge impact on our life as well asRead MoreVideo Games and Violence1011 Words   |  4 Pagesare probably millions and billions of video games sold every year to people. Some people seem to believe that violence correlates directly with video games. Video games are something that is usually a big interest in people at the ages of 13 to 19 years old. Video games usually start off as a little fun and then turn into a major hobby for some people. Emotions change based on whatever happens while a person is engaging in these games most of the time. These games are another way to observe how p eopleRead MoreVideo Games Violence664 Words   |  3 PagesUNV - 104 August 11, 2013 Video Games and Violence Video games and violence have different effects on children according to the type of video games that is being watched It is important to understand the world of video games. All video games do not prevent violence in children. Parents should take into consideration in monitoring their child while choosing video games. Depending on the video game that is chosen, does not mean the child will result in violent behavior later on in lifeRead MoreViolence in Video Games770 Words   |  3 PagesIn the article from Thom Gillespie states that Grand Theft Auto (GTA) is the latest video game to be known of demeaning our society’s youth in the U.S. He states though however, video games such as GTA are â€Å"art† and deserve protection. Moreover, those games just mirror humanitys violent instincts; they do not provoke violence, Gillespie argues. These games also offer chances for debates about ethical issues and the costs of actions. It is known from his writings that Thom G illespie is a professor

Legal Aspects of Supply Chain Management Essay - 2010 Words

Legal Aspects of Supply Chain Management Internet has definitively changed the relationships of the company with the different business partners of the supply chain. E-Commerce/E-Business is any ‘net’ business activity that transforms internal and external relationship to create values and exploit market opportunities driven new rules of the connected economy.†(Damanpour 2001). It refers to all forms of business activities conducted across the internet. This can include E-tailing, B2B, intranets and extranets, online advertising (e.g. advertising banners), and simply online presences of any form that are used for some type of communication (customer service for example). With internet the†¦show more content†¦Contracting via internet involves some problems and issues such as the validity of a contract in the web, the e-signature, which jurisdiction and law may apply to you and the problem of the taxation. I explored some problems of contracting online. The article 5 chapter II of the EU directive 2000/EC explains that before contracting, general information about the seller must be provided. â€Å"As there is no place to negotiate, a website should make clear where a business is located e.g. by ensuring all main entry and information pages on the site include the companys location† and â€Å"give a list of applicable terms and conditions† (Elborne 2000). The seller must provide his name, geographic and electronic address, full price etc. and â€Å"where the activity is subject to an authorisation scheme, the particulars of the relevant supervisory authority†Ã‚ ². The buyer must have complete information of the service provider and must be able to contact him rapidly. Basically the law of traditional contract must be applied in the same way in the electronic commerce however in internet is to know when and where the contract is formed. The seller should â€Å"make clear the procedure that must be followed be fore the contract is formed† (Elborne 2000). The acceptance of the offeree is very important because without acceptance there is no contract. In UK, theShow MoreRelatedAspects Of Supply Chain Management1209 Words   |  5 PagesAspects of Supply Chain Management Introduction The basic reason for negotiating a contract is to reduce risk, and establish who bears the cost of the risk incurred. Identifying the responsibility of the parties and avoiding finger pointing when a business operation goes bad. Perkins (2008), in studying risk and reward contracts states that risk and reward contracts are highly specialized, and require careful and creative management to create. In constructing a risk and reward contract they takeRead MoreLogistics And Supply Chain Management1379 Words   |  6 Pagestechnology and the consulting firms that service them, they are scrambling to hire people with Supply Chain expertise, but these experts are hard to come by. Supply Chain Management has moved from a necessary evil to a core competency at companies across industries. I am applying for admission to the Master of Logistics and Supply Chain Management because I want a career in the Supply Chain Management. In particular, I am interested in factors that affect the competitive performance of a businessRead MoreGlobal Nature And Systemic Impact On The Firm s Financial Performance968 Words   |  4 Pagesfinancial performance, the supply chain arguably faces more risk than other areas of the company. 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ReviewRead MoreNike Macro Environmental Analysis Essay699 Words   |  3 Pages Mahendranath Gunti BUS 510 - Marketing Management Westcliff University Instructor: Dr. Geraldine Goodstone Nike is a global brand headquartered in the United States, Europe, and the Asia Pacific region, specialized in the manufacturing of athletic apparel, footwear, accessories and equipment. Nike products can be found in over 20,000 retail stores. This paper focuses on the six macroeconomic factors (political, Economic, Social, Technology, Legal and Environmental) that impacts Nike’s productsRead MoreReckitt Benckiser Supply Chain in Practice: Challenges and Recommendations.1465 Words   |  6 Pagesis ranked as the number two anti-acne treatment worldwide. The company s Air Wick is ranked second in the air care segment worldwide. This strong portfolio of brands significantly fuels the revenues and profitability of the company. 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Should Marijuana Be Legal - 3165 Words

Marijuana has a number of names, however, there are a few which have gained notoriety and are crucial to understand if one is to appreciate stoner literature or life style. Marijuana Marijuana is in many ways the original name. When Spanish immigrants came into the US they brought marihuana with them for both spiritual and recreational purposes.This is the technical name, the one you ve learned in DARE programs and seen plastered all over the internet in anti-drug campaigns. Typically, this is an accurate representation of who uses this name officials of some sort who do not actually smoke marijuana. Stoners usually employ second nature pet names or only use the term marijuana if they feel lazy or want to be either especially†¦show more content†¦Recently and perhaps paradoxically, cannabis has become the technical name for marijuana that professionals interested in psychedelic research, or psychonauts, will employ. This is because cannabis is a term for respect without all the negative attachments marijuana holds. WORKS CITED Shorter Oxford English Dictionary (6th ed.), Oxford University Press, 2007, ISBN 978-0-19-920687-2 Ganja Summary The Archives of General Psychiatry published a landmark study in 2010 that found early marijuana use is associated with psychosis-related outcomes in young adults. When teenagers had used marijuana by the age of 15, researchers in Australia concluded that a statistically significant percentage of them developed psychosis by early adulthood. Since the researchers only looked at paired siblings, they reduced or eliminated the effects of genetic and environmental factors that may have skewed previous studies, an effect known as residual confounding. The researchers from Queensland stated bluntly: the longer the duration since first cannabis [marijuana] use, the higher the risk of psychosis-related outcomes. The study, entitled Association Between Cannabis Use and Psychosis-Related Outcomes Using Sibling Pair Analysis in a Cohort of Young Adults, measured non-affective psychosis, hallucinations, and PetersShow MoreRelatedShould Marijuana Be Legal?1609 Words   |  7 PagesMs. Fingarson English 11 March 9th, 2017 Junior Research Paper: Marijuana Should Be Legal. According to world recognized American Scientist Carl Sagan â€Å"the illegality of cannabis is outrageous, an impediment to full utilization of a drug which helps produce the serenity and insights , sensitivity and fellowship so desperately needed in this increasingly mad and dangerous world†. These are just some of the benefits of Marijuana along with many others. All you have been taught about cannabis inRead MoreShould Marijuana Be Legal?1060 Words   |  5 PagesMedical Marijuana Marijuana is the most commonly used illicit drug in the United Sstates (Wagner).. Marijuana is commonly used becauseThis it is because marijuana is easy to get and doesn’t have the visibly dangerous effects that other drugs like cocaine and heroine have. However,But does that mean marijuana is harmless to the human body? There are some people and studies that believe it is harmlessso. Sanjay Gupta, MD, Chief Medical Correspondent for CNN, wrote the following: â€Å"Frequent marijuana useRead MoreShould Marijuana Be Legal?986 Words   |  4 Pages smoking pot in California, is legal. On Tuesday, November 8, 2016, California became the fifth state to legalize the recreational use of pot. By a margin of about 56% to 44%, voters passed Proposition 64. With its passing, California is now among states like Colorado, Washington, Oregon and Alaska who have also legalized marijuana. â€Å"Marijuana could become quite the cash crop† said Richard McGowan, a professor at Boston College and expert in the field of marijuana legalization. While many peopleRead MoreShould Marijuana Be Legal?1230 Words   |  5 PagesCannabis Can The marijuana movement is more prevalent now than ever. Just recently, two other states have joined Colorado and Washington in the legalization of the recreational use of marijuana. On the other hand, the state of Florida did not pass the bill to approve medical marijuana. Although more and more states have begun to see the benefits in legalizing marijuana, many states maintain the view that smoking marijuana is criminal despite the many advantages it poses. Marijuana offers medical andRead MoreShould Marijuana Be Legal?997 Words   |  4 Pagesof the topics; write a thesis statement and complete the introduction 1. Marijuana should be legal, because it is harmless, and it is an effective medicine for many kinds of diseases. - Marijuana should be legal due to its variety of health benefits - Marijuana is an effective medicine for many kinds of diseases - Marijuana legalization would help boost the economy Thesis Statement: Why shouldn’t marijuana be legal due to its variety of health benefits, its effectiveness for combating manyRead MoreShould Marijuana Be Legal?864 Words   |  4 PagesCannabis, also known as marijuana among other names, is a preparation of the Cannabis plant intended for use as a psychoactive drug or medicine. Marijuana smoking remains the most prevalent form of illicit drug use in the United States and has even been legalized medicinally in twenty-four states. Four of these states, including Colorado and Washington, have legalized marijuana for recreational use. This means that it is treated like a controlled substance, like alcohol or tobacco, and anyone theRead MoreShould Marijuana Be Legal?1630 Words   |  7 PagesMarijuana has been a hot topic of conversation over the last few years, as some states in America have legalized it medically and recreationally. By discussing the legal aspect of marijuana, the economic benefits, medical usage and how marij uana affects the family, we can see the positive and negative impact that marijuana has on sociology. Except for a few select states, marijuana usage, sale and distribution of marijuana is in some manner illegal. As a result, there is immense legal considerationsRead MoreShould Marijuana Be Legal?1610 Words   |  7 PagesSince the very first day marijuana began dominating our country over 30 years ago, federal control of the drug has been the topic of an continuing arguments. Marijuana is a crushed up blend of dried out herbs, seeds and stems of the plant cannabis. Most people inhale it in the shape of cigarettes for pleasure and relief. Should marijuana be made legal? Advocates of the drug argue that there are multiple medical advantages and that tobacco and alcohol are far more harmful for us than the drug itselfRead MoreShould Marijuana Be Legal? Essay1261 Words   |  6 PagesMarijuana is safer than tobacco and alcohol, more beneficial and healthier too. Marijuana, unlike tobacco and alcohol, never causes serious illnesses like cancers of the lungs, throat, and mouth, cirrhos is, dementia, or anything else. In actuality, medical marijuana is used to treat cancer cells. â€Å"The earliest use of cannabis as a medicine is attributed to the legendary Chinese Emperor Shen Nung, who is thought to have lived around 2700 BC.. Cannabis sativa is thought to have been grown for at leastRead MoreShould Marijuana Be Legal? Essay965 Words   |  4 PagesShould Marijuana Be Legal? In order to start a discussion about whether marijuana should be legal, we must first begin with the history of marijuana. How long has marijuana been around? The earliest recorded use of marijuana is from the island of Taiwan off the coast of mainland china over 10,000 years ago in the Stone Age (Marijuana, 2014). They wove their clothes and made their shoes from hemp. The first paper was made from a combination of crushed hemp fibers and mulberry tree bark. This

Angiotensin II- and Salt-Induced Kidney Injury

Questions: 1. What are the novel findings the manuscript Angiotensin II- and Salt-Induced Kidney Injury? 2. What is the effect of low and high salt on blood pressure and kidney function in normal mice (C57)? 3. What is the mechanism of actions of hydralazine and eplerenone? 4. Why there is an increase level of plasma aldosterone in THM mouse model? 5. What are the mechanisms involved in Ang II/salt-induced nephropathy? 6. What did you find most difficult or interesting regarding the assignments? Answers: 1. The novel findings in Angiotensin II- and Salt-Induced Kidney Injury is that activation of Rac-1/ MR cascade is responsible for the renal dysfunction. The Rac-1 and MR cascade activated by the increasing the concentration of plasma aldosterone and to inhibit renal injury, a selective mineralocorticoid (MR) inhibitor such as eplerenone or adrenalectomy found to beneficial in deactivating MR signaling. 2. The effect of low and high salt concentration on blood pressure and kidney function in normal mice (C57) is that systolic blood pressure (SBP) and urinary albumin excretion showed no significant changes in C57 as compared to THM-HS mice. This relates that Ang II with high salt concentration is responsible for salt sensitivity of BP and kidney injury, not high salt concentration alone. 3. Eplerenone is a selective mineralocorticoid (MR) inhibitor. The PAI-1, CTGF, Sgk-1 are the effectors of MR signalling in the kidney. MR signalling also activated by increasing salt concentration. The renal dysfunction and MR activation is dependent on plasma aldosterone status. It inhibit MR activation and hence reduced albuminuria. Hydralazine helps to lower systolic blood pressure but does not improve condition related to salt induced albuminuria, podocyte injury or renal abnormalities. 4. The plasma aldosterone levels were increased in THM-LS mice as compared to C-57, because high concentration of salt reduces plasma aldosterone concentration but activated renal RAC-1 MR cascade and thus caused renal dysfunction. 5. Adrenalectomy suppressed the activation of both Rac-1 and MR signalling cascade. Therefore, aldosterone/MR system is involved in the Ang II/salt-induced nephropathy. The effect of adrenalectomy and aldosterone supplementation was examined in TMS-HS. The adrenalectomy reduced plasma aldosterone and thus reduced BP and prevented albuminuria, whereas aldosterone supplementation increases plasma aldosterone and thus BP increases and caused renal dysfunction. 6. The most interesting part is to reveal the action of the Rac-1/ MR cascade, that is, how Rac-1/ MR cascade gets activated and causes renal dysfunction and how renal dysfunction caused by Ang II/ salt. The most difficult part is to understand the mechanism of Mineralocorticoid cascade in the renal dysfunction and to interpret the data in finding out the causative agent of renal dysfunction. References: 1. Kawarazaki W. (2012). Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation. J Am Soc Nephrol. 23, pp. 9971007.2. Nagase M. (2010). Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome. Clin Exp Nephrol. 14, pp. 303314.3. Shibata S., Nagase M., Yoshida S., Kawarazaki W. (2008). Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease. Nat Med. 14, pp. 13701376.4. Lea W. (2009). Aldosterone antagonism or synthase inhibition reduces endorgan damage induced by treatment with angiotensin and high salt. Kidney Int. 75, pp. 936944.